About City of Hope
Please note, this is not a remote position
City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.
Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.
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Position Summary
The Clinical Variant Curator assists the clinical and developmental operations of the Clinical Diagnostic Molecular Genetics Laboratory (CMDL) to accurately identify and precisely classify variants/mutations detected through standard molecular genetic testing.
Duties include assisting clinical laboratory leadership as a resource for ongoing test development and clinical testing pipelines in conjunction with the interpretation and classification of genetic variants.
Key Responsibilities include:
- Use comprehensive knowledge of scientific theory and departmental policies and procedures to curate genetic variants/mutations detected through standard molecular genetic testing using information from existing databases and from literature.
- Participate as a productive member of the work team.
- Maintain continued involvement in professional development through participation in educational opportunities to ensure continued adherence to standards and provision of quality laboratory care.
- Follow policies/procedures/regulatory requirements and perform other work assignments.
- Curate genetic variants/mutations applicable to the CMDL offerings.
Minimum Education:
- Master's Degree in Biological Sciences and familiarity with Germline databases, Sanger Sequencing and Next-generation sequencing (NGS) or Bachelor's Degree and familiarity with Germline databases, Sanger Sequencing and Next-generation sequencing (NGS) and 2 years of sequencing data interpretation.
- Knowledge of principles and practices of computational biology as applied to genetics/genomics. An understanding of bioinformatics analysis to identify variants within genomic data sets, and variant effect prediction algorithms. Laboratory and/or clinical experience in cancer genetics. The ability to critically read, understand, and interpret data from scientific publications. Cross-disciplinary and strong analytical skills as well as broad experience using computational methods, databases, software and hardware.
- 2 years of sequencing data interpretation is desirable with Master's Degree in Biological Sciences.
- Posting Date: Sep 22, 2021
- Job Field: Allied Health
- Employee Status: Regular
- Shift: Day Job