Senior Manager, Brand Strategy & Commercial Excellence

Location(s): Rome, Italy

Level of position: Senior Manager

Position type: office-based, in alignment with BlueFlex model

Reporting Line: Country Manager and Commercial Lead Italy

How will your role help us transform hope into reality?

We are seeking a highly motivated and entrepreneurial Senior Manager, Brand and Commercial Excellence to lead brand strategy, optimize sales force performance, and support local market access initiatives. This role requires a blend of marketing expertise, sales force excellence, forecasting & operational planning, performance analysis, and leadership through influence to drive brand success in a competitive environment.

Reporting into the Country Manager and Commercial Lead Italy, the ideal candidate will be strategic yet hands-on, comfortable navigating ambiguity, and passionate about making a difference in patients’ lives.

What will you do?

• Develop and implement brand strategies and tactical plans, aligning with global, international and regional teams
• Lead omnichannel and digital marketing initiatives to enhance HCP engagement and brand awareness.
• Monitor and adapt marketing activities based on market dynamics, competitor intelligence, and customer insights.
• Ensure effective budget management, tracking ROI and adjusting resource allocation as needed.
• Analyze sales data and performance metrics to generate actionable insights that drive brand and commercial strategy.
• Optimize territory performance, identify trends, and address gaps.
• Develop and track commercial KPIs, leveraging data-driven insights to improve sales force execution.
• Support territory and segmentation analysis to refine targeting strategies and improve field effectiveness.
• Develop and maintain accurate short-term and long-range forecasts using advanced models to support strategic planning.
• Collaborate with supply chain teams to ensure supply forecasts are aligned with demand fluctuations and evolving market conditions.
• Provide data-driven insights to anticipate trends, mitigate risks, and optimize inventory management in a rare disease setting.
• Design and execute sales force training programs, ensuring clear communication of brand value propositions.
• Optimize sales team performance by implementing best-in-class tools, analytics, and engagement strategies.
• Act as a strategic partner to sales teams, fostering leadership through influence rather than direct authority.
• Collaborate with local market access teams to ensure alignment of brand strategies with payer needs
• Support the development of value propositions, pricing strategies, and reimbursement initiatives.
• Maintain field presence, engaging with KOLs, external partners, and sales teams to stay connected to market realities.
• Collect and analyze competitor intelligence, identifying opportunities and risks for the brand.
• Work closely with Medical, , Sales, Market Access, Supply Chain, and International Marketing and Comercial Operations teams.
• Identify and act on new opportunities to enhance brand positioning and commercial impact.
• Foster a culture of agility, ownership, and strategic problem-solving within the team.

What minimum qualifications do we require?

• Bachelor’s degree. MBA preferred.
• 5+ years of experience in marketing, digital and commercial excellence in biotech/pharma. Experience in sales and other field roles preferred.
• Strong understanding of Italian pharmaceutical environment and specialty care.
• Proven track record in brand strategy and execution, omnichannel marketing, forecasting, and sales force optimization.
• Proven track record in successful product launches in specialty care and opening new markets.

What additional qualifications will make you a stronger candidate?

• Experience working in cross-functional and highly collaborative environments and in matrix organizations.
• Ability to lead through influence and drive results without direct authority.
• Strong analytical skills, with experience in sales performance analysis, forecasting models, long-range planning (LROP), and supply chain interaction.
• Entrepreneurial mindset with a hands-on approach and ability to adapt to fast-changing market conditions.
• Commitment to our Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism

Why Blueprint? 

At Blueprint Medicines, we achieve impactful results because of our global crew of compassionate innovators – the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success.

This is the place where the extraordinary becomes reality, and you could be part of it.

Patients are waiting. Are you ready to make the leap?

Blueprint Medicines is a global, fully integrated biopharmaceutical company that invents life-changing medicines. We seek to alleviate human suffering by solving important medical problems in two core focus areas: allergy/inflammation and oncology/hematology. Our approach begins by targeting the root causes of disease, using deep scientific knowledge in our core focus areas and drug discovery expertise across multiple therapeutic modalities. We have a proven track record of success with two approved medicines, including bringing our medicine to patients with systemic mastocytosis (SM) in the U.S. and Europe. Leveraging our established research, development, and commercial capability and infrastructure, we now aim to significantly scale our impact by advancing a broad pipeline of programs ranging from early science to advanced clinical trials in mast cell diseases including SM and chronic urticaria, breast cancer and other solid tumors.

*Blueflex is our operating model which optimizes culture, productivity, & flexibility by maximizing the critical strengths of in-person work with the benefits of added flexibility.  Blueflex allows for mix of in-office and remote work, enables flexibility to meet individual and business needs and makes effective use of our facilities and resources.  It is a culture enhancer.

#LI-Hybrid #LI-NJ1