Work Schedule
Standard (Mon-Fri)
Environmental Conditions
Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)
Job Description
Thermo Fisher's clinical research business is a leading global contract research organization and world leader in serving science. We are passionate, deliberate, and driven by our mission - to enable our customers to make the world healthier, safer, and cleaner.
Within our Analytical Services team, we have a functional service provider solution, which is a unique partnership that allows our customers to maximise the experience of our staff, while allowing you, the employee, to gain direct experience working onsite at a pharmaceutical/ biopharmaceutical company, all while maintaining full-time benefits.
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Essential Functions:
The target client is a leading pharmaceutical group responsible for the development of CHO based production cell lines, next-gen cell line engineering efforts and baseline upstream process development for innovative recombinant protein/adjuvanted vaccine projects and platforms. The target client is looking for a motivated professional, specialized in commercial cell line development, CHO protein vaccines. This role will play a significant role in shaping current and next generation leading vaccine platforms to accelerate addressing unmet medical needs, an exciting field having a direct impact into patients and global health. This role provides the opportunity to integrate a diverse group of top dedicated experts in vaccines' industry, lead key activities and further grow and progress in your career.
Main core responsibilities:
A. Design and Development of preGMP-grade CHO cell lines for commercial manufacture of recombinant protein vaccine products.
B. Serve as a key teammate to support project documentation and CMC regulatory submissions (including raw material control section and cell line derivation report)
Education and Experience:
Bachelor's degree in a degree related in Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology, Bioengineering, or a related scientific field.
- Previous proven experience that provides the knowledge, skills, and abilities to perform the job:
- Scientist: With a bachelor's degree comparable to 2+ years
- Hands-on experience with aseptic mammalian (CHO cell preferred) cell line development, especially transfection, single cell isolation, derivation, suspension cell culture at small scales ranging including 96 well-plate, 24 well-plate and shake flask formats.
- Experience with expression vector design and optimization for complex recombinant protein production.
- Experience with good documentation practices and reports as evidenced by conference proceeding, peer-review publication and/or equivalent.
In some cases, an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.
Preferred Qualifications:
- Solid understanding in the cell line development for vaccine and biologicals production in the industrial setting (including a strong CMC understanding)
- Prior experience in the high-throughput, robotic cell line screening tools (including FACS and Beacon et al) or other high-throughput robotic systems
- Experience with common nucleic acid- and protein-based analytic assays (including PCR, Luminex and Octet) for early product quantity and quality assessment to support cell line selection. .
Working Environment:
- PPD values the health and well being of our employees. We support and encourage individuals to create a healthy and balanced environment where they can thrive. Below is listed the working environment/requirements for this role:
- Able to communicate, receive, and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner.
- Able to work upright and stationary and/or standing for typical working hours.
- Able to lift and move objects up to 25 pounds
- Able to work in non-traditional work environments.
- Able to use and learn standard office equipment and technology with proficiency.
- May have exposure to potentially hazardous elements, including infectious agents, typically found in healthcare or laboratory environments.
- Able to perform successfully under pressure while prioritizing and handling multiple projects or activities.