About the Job

We are an innovative global healthcare company that helps the world stay ahead of infectious diseases by delivering more than 500 million vaccine doses a year. Across different countries, our talented teams are exploring new technologies to protect people and promote healthy communities. We chase the miracles of science every single day, pursuing progress to make a real impact on millions of patients around the world.

At this time, Sanofi will not sponsor a new applicant for employment authorization, or offer any immigration related support for this position (i.e. H1B, F-1 OPT, F-1 STEM OPT, F-1 CPT, J-1, TN, or another type of work authorization).*

Essential Duties and Responsibilities:

• Thecandidate is expected to learn how touse structural biology tools such cryo-EM and/or X-ray crystallography to elucidate antigen-antibody complex structures
  
• Thecandidate is expectedto prepare negative staining EM samples and perform data collection and data analysis using cryoSparc or equivalent
  
• Thecandidate will participate in the cryo-EM sample preparation & optimization, grid screening and data collection using cryogenic electron microscope (Glacios and Krios)
  
• Thecandidate will perform cryo-EM data processing using cryoSparc or equivalent and model building using Phenix, Coot and Isolde
  
• The work involves the interpretation of biochemical resultsof antigen-antibody complexes (ELISA, SPR, BLI etc)
  
• The work also involves the data analysis for protein quality (SEC, DSF, DSC etc)
  
• The candidate is expected to generate in-silico structural model using Alphafold or other protein modeling algorithms
  
• The candidate is expected to have a solution-focused, team-oriented mindset and will interact closely with other investigators in research and development of novel vaccine candidates
  
• This is a hands-on, laboratory-based role in a highly collaborative research environment
  
• Role will require planning, designing, executing, interpreting, and presenting data in an effective and scientific manner
  
• Participate in scientific discussions focusing on current technology of structural biology
  
• Maintain detailed records and communicate progress and challenges, as necessary
  
• Perform timely electronic laboratory notebook entries, review and submission for completed experiments.
  

• Currently pursuing a PhD in Molecular Biology, Biochemistry, Biophysics, Structural Biology, or closely related discipline
  
• Must have permanent US work authorization
  
• Must be able to relocate to our Waltham office location and complete the full duration on the Co-op
  
• A background in structural biology is required
  
• Ability to independently design, plan and execute scientific studies, including operation and maintenance of relevant instruments and troubleshooting are required
  
• Strong interpersonal, communication, collaboration and problem-solving skills are needed
  

• Experience with cryo-EM sample preparation and grid clipping is preferred
  
• Experience with cryo-EM data processing and model building is preferred
  
• Deep knowledge and hands on experience with the biochemical and biophysical tools (SPR, BLI, DSF, SEC etc.) is preferred
  
• Advanced skill in structural viewing program such as Pymol and ChimeraX is preferred
  
• Familiarity with viral fusion protein and antibody biology is preferred
  

• Bring the miracles of science to life alongside a supportive, future-focused team.
  
• Discover endless opportunities to grow your talent and drive your career, whether it's through a promotion or lateral move, at home or internationally.
  
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
  
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks' gender-neutral parental leave.