Job Title: Senior Scientist, Gene Therapy Immunology

Grade: L2-2

Hiring Manager: Lavesh Gwalani

Location: Waltham, MA

About the Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress.

The Genomic Medicine Unit is seeking a highly motivated candidate with a strong background in Immunobiology for a Sr. Scientist role that will help build innovation in Gene Therapy Immunology.

Host immune response to non-viral gene therapy and adeno-associated viral vectors (AAV) is a key challenge for clinical adoption. The successful candidate will work transversally with members of various research groups including capsid engineering, large molecule research and computational biology teams to develop strategies aimed at minimizing adaptive immune responses to LNP and AAV. Working in this bench-research position, the candidate will explore the use of Sanofi's proprietary immunomodulatory molecules to dampen host immunological response to gene therapy administration. Participation will provide the candidate a tangible opportunity to contribute to development of novel genomic medicine approaches for rare diseases with unmet need.

• Play a key role in driving research efforts in testing Sanofi molecules in vivo and in vitro to determine immune modulation by these molecules with a focus on adaptive immune responses
  
• Provide in vivo pharmacology expertise for the design and implementation of in vivo studies in mice and NHPs
  
• Identify, develop and optimize / troubleshoot in vitro and / or ex vivo assays for determining adaptive immune responses to AAV and LNP in human/mouse/NHP primary cells
  
• Responsible for independently executing experiments in a time sensitive manner
  
• Develop and maintain a culture of teamwork and collaboration
  

• Ph.D. in immunology or immunology-related discipline with 3+ years post-doctoral experience in immunology research
  
• Demonstrated ability to design, execute, interpret, and present experimental results from in vivo studies and in vitro cell based assays for small molecules/biologics with immune-modulatory activity
  
• Experience with developing and working with mouse models to evaluate immune responses.
  
• Ability to manage multiple projects in parallel, communicate clearly and effectively and build open and collaborative relationships with scientists from multiple groups.
  
• Flexibility to adapt to rapidly changing priorities and deadlines in a dynamic, fast paced work environment
  

• Relevant industry experience / research background in immune modulation and/or immune tolerance
  
• Experience with a range of in vivo skills, including but not limited to conventional routes of dosing administration and harvesting tissues and blood
  
• Experience in identifying CRO resources, design and manage studies and establish strong capabilities in an outsourced setting
  

• Bring the miracles of science to life alongside a supportive, future-focused team.
  
• Discover endless opportunities to grow your talent and drive your career, whether it's through a promotion or lateral move, at home or internationally.
  
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
  
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks' gender-neutral parental leave.