Le contenu du poste est libellé en anglais car il nécessite de nombreuses interactions avec nos filiales à l'international, l'anglais étant la langue de travail.
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Job title:Senior Scientist DP Development
About the job
In the race for the future of health - The Sanofi mRNA Center of Excellence (CoE)
At Sanofi, we chase the miracles of science, and we know mRNA has a role to play in the future of health. And while the pandemic has shaken up our industry, creating new opportunities and risks, we believe the acceleration of innovation with mRNA technology means vaccines and treatments for more people faster than before.
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That's why we're looking for bold, optimistic world-changers to join our mRNA Center of Excellence. We're investing €400m a year into the new Center, hiring a team of 450 dedicated employees, and focusing on implementing an integrated end-to-end mRNA vaccine capabilities and research with R&D, digital and CMC teams.
Bring your ambition and optimism and join us on our journey to discover and deliver transformative medicine to patients through the advancement of our cutting-edge mRNA technology!
Our Team
The mRNA - Senior Scientist Drug Product Development is part of the Global Drug Product Development (GDPD) group within the mRNA CoE. GDPD is responsible for developing the Drug Product formulation and manufacturing process in support of all ongoing mRNA Vaccine programs within the CoE from Phase 1 through Phase 3 and commercialization. GDPD achieves this through internal collaborations with our colleagues in US and through constant collaboration with other departments including Drug Substance Development, Analytical Sciences, Research, Process Industrialization, Global Process Harmonization & Tech Transfer, and cGMP Strategic Supply & Operations. GDPD's mission is to develop safe, stable, and patient-centric mRNA vaccine and therapeutic Drug Products and associated robust manufacturing processes.
Main responsibilities:
- Apply scientific expertise and judgment to initiate, design and execute or supervise execution of the development of liquid and lyophilized mRNA-LNP drug product formulation and process
- Make scientific presentations and report project progress within mRNA CoE Formulation teams and with partners and in international forums
- As a Subject Matter Expert in drug product development, be an impactful contributor to project teams and actively participate in DP sub-teams
- Provide consolidated DP development technical work packages with timelines, resources and critical path activities
- Drive organizational goal of rapidly incorporating innovative advances in drug product platform (thermostable formulations and process improvements)
- Promote innovation, state of the art technologies, and propose strategies using publications to improve the products
- Proactively collaborate with other functions to meet projects and platform milestones
- Proactively collaborate with other groups or sites in transfer of information, materials and drug product technology
- Promote internal assessment of new DP technologies and scientific network to leverage internal and external expertise
- Make decisions that require developing new options to solve moderately complex problems
- Demonstrate continuous growth in depth and breadth of personal scientific knowledge and understanding of strategic goals of group, team, and company
- Maintain a consistent record of publications, patents, external presentations
- Proactively participate in laboratory organization (including HSE, quality aspects) and continuous improvement of WoW
- Supervise lab activities with technicians, internships and TPW (indirect report), when appropriate
About your development opportunities
In this role, you will gain a technical understanding of mRNA vaccine drug product development, drug product characterization techniques, and process development study design strategies. You will be exposed to, and gain an understanding of, what other technical function are responsible for and how they all play a role in mRNA vaccine development. You will have the opportunity to collaborate and learn from management within GDPD as well as other departments.
About you
- Experience: Experience in CMC activities and project management, parenteral drug product development and industrialization required. Understanding of complex R&D landscapes globally, ability to identify cutting-edge technologies and new directions, strong academic and biotech/pharma scientific networks
- Soft skills: Good oral communication, proactive, organized, passionate about scientific progression, leadership, and interpersonal skills. Ability to work in a fast-paced environment
- Technical skills: Formulation, Physical-chemistry of nanoparticles and associated characterization methods, pharmaceutical engineering, knowledge on different unit operations of drug product manufacturing (Lipid Nanoparticles manufacturing, TFF, Freeze/Thaw, mixing, filtration, Fill&Finish, lyophilization), process modelization, digital tools
- Education: Biochemistry, chemistry, pharmaceutical engineering or related degree, PhD
- Languages: French & English
PursueProgress.DiscoverExtraordinary.
Progress doesn't happen without people - people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. You can be one of those people. Chasing change, embracing new ideas and exploring all the opportunities we have to offer. Let's pursue progress. And let's discover extraordinary together.
At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, or gender identity.
Watch ourALL IN videoand check out our Diversity Equity and Inclusion actions atsanofi.com!
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