Principle Scientist - Computer-Aided Drug Discovery (CADD), Integrated Drug Discovery
About the Job
We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people's lives. We're also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?
Job Overview
An accomplished computational chemist, with a strong track record of medicinal chemistry project contributions, experience in multiparameter optimization, and de novo small molecule design.
Responsibilities
- Act as CADD lead for medicinal chemistry projects and initiatives.
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About you
Requirements & Qualifications
- Ph.D. in computational chemistry, chemical informatics, physical organic chemistry, biophysics, medicinal chemistry or related field with minimum of 10 years of relevant research experience in an academic or biopharmaceutical setting.
- Strong understanding of computational modeling techniques includes QSAR methods, pharmacophore development, 2-D and 3-D similarity, data mining and visualization, protein modeling, conformational analysis, molecular docking, and library analysis and design.
- Proficient in the use of modeling techniques and capable of developing and automating workflows.
- Demonstrated experience in developing and applying predictive method for on- and off-target activity, physicochemical and ADME properties.
- Demonstrated experience in multi-parameter optimization by designing small molecule targets with synthetic feasibility and foundational understanding of organic chemistry, medicinal chemistry, and DMPK principles.
- Demonstrated skills in developing and implementing AI-based algorithm and method for compound design.
- Consistent record of publications, patents, external presentations, and involvement in professional societies.
- Demonstrated ability to develop new ideas to solve complex problems to move projects forward.
Why Choose Us?
- Bring the miracles of science to life alongside a supportive, future-focused team.
- Discover endless opportunities to grow your talent and drive your career, whether it's through a promotion or lateral move, at home or internationally.
- Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
- Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks' gender-neutral parental leave.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
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