About the job

Our Team:

At Sanofi, we chase the miracles of science to improve people's lives. In the Global CMC department of R&D we develop industrial-scale production processes to bring our pipeline molecules to the patient. As part of the Microbial Platform in Frankfurt, we are developing cutting edge manufacturing processes for the next generation of microbial-derived biologics.

To support our Host Strain Engineering Team in Frankfurt, we are looking for a highly self-motivated, innovative molecular biologist with passion for microbial biotechnology and synthetic biology who is eager to bring research into application.

Main responsibilities:

• Work independently as a fully integrated member of a cross-functional, interdisciplinary, and international CMC development team
• Lead planning, design, execution of molecular biological experiments, strain engineering and process development
• Development, evaluation, and implementation of new methods or application and optimization of existing state-of-the-art process-relevant methods and molecular biological techniques
• Establishing and optimizing CRISPR-methods for Pichia pastoris (Komagataella phaffii) genome editing as basis for engineering of strains heterologous protein production and industrial manufacturing processes
• Data analysis and data interpretation, presentation and reporting of results to international and interdisciplinary audience
• Follow, review, and share the latest project-related innovations and technology breakthroughs in academia and industry
• Contribute to collaborations with academic institutions

• Ph.D. with experience in molecular biology, microbiology, biochemistry, and microbial expression systems
• Track record within the field of recombinant protein expression technology, synthetic biology, and strain engineering with strong focus on yeast, especially Pichia pastoris (Komagataella phaffii)

• Experience with DNA sequence design, cloning software (SnapGene, Benchling etc.) and modern molecular cloning techniques (Golden Gate, Gibson assembly, etc.)
• Strong experience with CRISPR technologies (ideally with focus on yeast) and microbial synthetic biology concepts
• Hands on experience and expertise on molecular cloning, yeast strain engineering and analytical characterization of microbial strains is required
• Experience with NGS (Illumina, ONP, PacBio) and NGS-data analysis for validation of engineered expression strains

• Passionate about biotechnology and synthetic biology
• Able to drive a scientific project from idea to application, "Can Do"-Attitude
• Demonstrated ability/willingness to quickly learn and perform in new areas, implement new

• Ability to plan and execute experiments independently, organized, rigorous and adaptative
• Elaborate, structured and accurate way of working
• Innovative mindset and entrepreneurial spirit
• Strong team player with analytical skills and interest to work in a highly interdisciplinary area
• Fluent in English, preferably good German skills

• Languages: German, English

• Bring the miracles of science to life alongside a supportive, future-focused team.
• Benefit from a well-thought-out benefits package that rewards your contribution and commitment.
• Start your career at an attractive location in the center of Germany and experience our modern working environment and benefit from hybrid, flexible working time models.