Genomic Medicine Purification Process Development Co-Op, Waltham, MA

About the job

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people's lives. We're also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Position Overview/Department Description:

The Genomic Medicine Unit (GMU) Chemistry, Manufacturing and Control (CMC) group at Sanofi is dedicated to the establishment of best-in-class manufacturing platforms to support development of life-changing advanced cell and gene therapy products, including recombinant Adeno-associated viral vectors (AAV), non-viral and cell therapy products. This 6-month position centers on drug substance process development for gene therapy but will interface with a broader team of vector and cell line engineering, upstream process development, analytics, and clinical manufacturing support.

• Design and execute viral vector purification experiments.
  
• Perform analytical characterization of samples and analyze results.
  
• Work with cross-functional team for feedback and present findings.
  
• Contribute to technical reports and/or external publications if appropriate to project topic and level of experience.
  

• Currently pursuing a PhD, MS, or BS degree in chemistry, chemical engineering, or biological engineering with relevant study experience.
  
• Must be enrolled in school the semester following your internship/co-op with Sanofi.
  
• Must be able to work in a hybrid work environment in our Waltham, MA office for the duration of the co-op
  
• Must have permanent US work authorization
  
• Understanding of drug substance purification process concepts.
  
• Theoretical and practical knowledge of mass transfer and fluid dynamics.
  
• Knowledge and understanding of technologies and operations such as:
  
  • Chromatography, tangential flow filtration, normal flow filtration, and/or viral clearance and inactivation
    
  • Advanced analytical tools to characterize particles and viral vectors
    
    
• Work under minimal supervision and function within a collaborative, team-oriented environment.
  
• Ability to work in Biosafety Level 2, follow safe lab procedures, and maintain good laboratory practices (GLPs) including detail-oriented laboratory notebook documentation.
  

• Experience with viral vector purification and characterization.
  
• Experience with SEC-HPLC, DLS, ddPCR/qPCR, Western blot, ELISA, spectroscopic and bioassay techniques.
  
• Experience with AKTA chromatography and filtration instruments.
  
• Experience with protein characterization such as NanoSight 3000, Caliper LabChip GXII, Multi-Angle LS (MALS), or similar instruments.
  
• Basic understanding of the principles of Quality by Design and ability to apply DOE to downstream development.
  
• Excellent communication skills and ability to build cross-functional relationships.
  
• Experience in protein characterization, high-throughput, engineering and data analysis, analytical techniques, and/or viral vector purification is preferred.
  

• Bring the miracles of science to life alongside a supportive, future-focused team.
  

• Discover endless opportunities to grow your talent and drive your career, whether it's through a promotion or lateral move, at home or internationally.
  

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
  

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks' gender-neutral parental leave.