ROLE SUMMARY
As a Senior Scientist, you will participate and play a critical role in pre-clinical drug discovery and development of ADC therapies spanning different payload classes. You will be responsible for designing and executing in vivo studies to evaluate the efficacy, safety and pharmacokinetics (PD)/pharmacodynamics (PD) relationship of ADC candidates. You will provide technical and scientific expertise in in vivo Pharmacology across Oncology R&D to enable target identification, validation, prioritization, and efficient drug discovery. You will collaborate closely with cross-functional teams to drive development of novel therapeutic agents from concept to clinic.
ROLE RESPONSIBILITIES
- Lead in vivo pharmacology studies, focused on evaluating and establishing efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.
- Design, develop and execute in vivo studies to evaluate and assess the therapeutic potential of ADC candidates in oncology models CDX/PDX/GEMM/Syngeneic models
- Work within multi-functional teams to support target identification, validation, drug discovery and combination therapy.
- Effectively manage study timeline and coordinate study logistics with cross functional program teams.
- Develop and characterize new in vivo mouse models, including cell-line derived xenografts, syngeneic tumor and genetically engineered mouse (GEM) models, to study biologic mechanisms and support exploration of novel cancer immune therapeutics and targeted therapies.
- Proficiency in utilizing software such as GraphPad Prism, electronic lab notebooks, Microsoft Office etc. for data analysis and figure generation
- Quality documentation and interpretation of experimental results
- Presentation of results within a multidisciplinary team environment.
- Ensure appropriate use of animals in compliance with all regulatory requirements and internal standards
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QUALIFICATIONS
Must Have
- Ph.D. in Cancer Biology, Immunology or related discipline
- Experience with animal models of human cancers.
- Proficiency in cell culture, passaging and harvesting cells is required.
- Hands on in vivo skills (IV, PO, SC, IP dosing), blood/tissue collection
- Excellent written and oral communication and presentation skills
- Experience integrating biological concepts into experimental design
Preferred
- Experience with GEMM and humanized models
- Experience with Antibody Drug Conjugates (ADC)
- Strong track record of publications or evidence of equivalent achievements in industry
PHYSICAL/MENTAL REQUIREMENTS
- Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis
- Must be able to wear specialized protective clothing and PPE (e.g., lab coat, safety shoes, safety glasses)
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
- Must be willing and able to work after hours as needed to ensure study integrity
PHYSICAL/MENTAL REQUIREMENTS
• Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis
• Must be able to wear specialized protective clothing and PPE (e.g., lab coat, safety shoes, safety glasses)
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
• Must be willing and able to work after hours as needed to ensure study integrity
Relocation support available
Work Location Assignment: On Premise
The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development