As a Senior Scientist in the Chemical Biology and Proteomics group your work will drive a deeper understanding of the mechanism of action of our molecules and cellular targets. Relevant methodologies include, but are not limited to global proteomics, protein-protein and protein-small molecule interactomes, identification of novel targets, small molecule target deconvolution, small molecule target occupancy studies using chemical probes.

Role Responsibilities

• Leverage mass spectrometry-based proteomics techniques for model characterization and molecular mechanism of action elucidation.
• Develop innovative chemical biology methods, with an emphasis on quantitative protein mass spectrometry technologies.
• Enable new small molecule projects in the portfolio, through collaborations with disease area biologists and chemists.
• Present and report data with follow up discussions for project teams including data impact and interpretation.

• Enhance the external reputation of Pfizer's Chemical Biology and Proteomics capabilities through publications and presentations at leading conferences.
• Drive innovation in all aspects of laboratory operations including sample preparation, running and maintaining mass spectrometers, data analysis and interpretation.
• Work with local leadership to put in place an active program of self-development in proteomics and chemical biology skills.

Qualifications

• Doctorate level degree in mass spectrometry-based proteomics/biochemistry/chemistry or related field with experience in chemical biology/chemo-proteomics. Post-doctoral experience is a plus.
• Hands-on experiences with high-resolution LC-MS instruments (e.g., QE-HF, Tribrids, Exploris 480, TimsTOF ) to ensure high-quality data.
• Experience with quantitative proteomics data analysis, including Proteome Discoverer, MaxQuant, Spectronaut, or equivalent analysis platforms is required. Some programming expertise is a plus.
• Experience in affinity-based MS and proximity labeling methodology preferred.
• Proficiency in protein biochemistry techniques (examples may include subcellular fractionation, western blot, in-gel fluorescence) is preferred.
• Familiarity with bio-orthogonal chemistry, site-selective protein modification, photo affinity cross-linking, activity-based protein profiling (ABPP) is a plus.
• Exceptional documentation and communication skills.
• Self-motivated and highly effective in a team-based environment.
• Examples of peer-reviewed publications from scientific work to date.

PHYSICAL/MENTAL REQUIREMENTS

• Lifting HPLC solvent bottles, pipetting at bench, ability to perform complex data analysis.

Other Job Details

• Last day to apply: December 6, 2024.
• Work Location Assignment: On Premise.

The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

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