• Establish in vitro systems using liver iPSC or primary hepatic cell cultures to develop tools that can recapitulate ADC-cell interactions that occur in-vivo

• Through the development and implementation of in vitro technologies, mechanistic hypothesis will be explored to define the structural characteristics of ADCs that contribute to pharmacologically undesirable interactions with liver cells that ultimately influence clearance and downstream toxicities.
• In vitro finding will be further confirmed by testing hypotheses in vivo pre-clinical models

Your strong foundation in molecular and cellular biology principles will enable you to take innovative approaches that will lead to achieving new milestones for the treatment of oncology patients.

How You Will Achieve It

Driving innovation, independent thinking, problem solving, and meticulous design, execution and interpretation of experiments under minimal supervision.

Collaborating and seeking guidance from subject matter experts, including toxicologists, complex cell culture specialists, cancer biologists, and protein scientists, to achieve project objectives.

Working with mentors to develop and apply complex in vitro assays to develop translatable models.

Presenting the research work at various internal and external meetings and conferences and publish in relevant peer-reviewed journals.

Contributing to building a culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and neurotoxicology expertise.

Ensuring all tasks and responsibilities are carried out according to scientific, ethical and regulatory standards.

Qualifications

Must-Have

Ph.D. in cell and molecular biology or related fields. No more than 2 years of post-degree experience

Demonstrated experience in diverse cellular, biochemical and molecular laboratory techniques with strong background in cell biology.

Possess experience using 3D IPSC or primary non-tumor cell cultures and/or microphysiologic systems

Well organized, self-motivated, team-oriented with ability to multitask with high attention to detail.

Strong collaborative spirit and communication skills.

Successful record of scientific accomplishments as indicated by scientific publications and/or presentations. At least one first-author publication in peer-reviewed scientific journals.

Willingness to make a minimum 2-year commitment.

Nice-to-Have

Experience in hepatic physiology and metabolism

Experience working with a variety of microphysiologic system

An understanding of pharmacology and toxicology principles

Experience handling and working with mice.

Relocation support available
Work Location Assignment: On Premise

The annual base salary for this position ranges from $60,900.00 to $101,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

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