ROLE SUMMARY

As a member of our Tumor Biology Group's Oncogenic Transcriptional Networks Team, you will focus on translating basic discoveries in the field of cancer epigenetics and oncogenic transcriptional programming into novel therapeutics.

You will conduct biology discovery supporting existing and emerging drug discovery programs in the group, leading a team of motivated and rigorous scientists to perform laboratory-based research in a collaborative team environment.

As a leader of the group, you will be involved in evaluation of small molecule inhibitors, target mechanism-of-action studies, interpretation and presentation of data, and will function as an integral member of the project teams to advance programs.

• Lead a laboratory research group to study genetic and epigenetic mechanisms in tumor biology with the aim to identify new therapeutic targets and approaches that can be translated to the clinic
• Work with interdisciplinary teams to advance small molecule drug discovery programs from early target validation through hit-to-lead campaigns.
• Utilize expertise in transcriptional regulation and epigenetic biology to design, execute, and analyze/interpret innovative approaches for epigenetic targeting in cancer.
• Work collaboratively with computational biology group to integrate complex data sets including epigenomic and other 'omic' data in pre-clinical settings for target discovery, validation, and advance mechanism of action target biology
• Lead development of cell and molecular assays to define target mechanism of action, measure pharmacodynamic changes and select responder patient populations.
• Interface with discovery biology and computational biology groups to design, develop, and interpret datasets developed from genetic and pharmacological screens
• Proactively seek out new information in the literature and incorporate this into individual project(s) as well as the overall program.
• Present research results and methodologies at weekly meetings with immediate supervisor and/or project leader, and at meetings with members of the oncology research unit as appropriate.
• Contribute to building a culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and cancer biology expertise; take a proactive role in personal growth and scientific development.

• PhD or MD/PhD in Molecular Biology, Pharmacology or a comparable biological science
• Minimum of 8 years of relevant post-degree experience in a pharmaceutical/biotech environment.
• Extensive knowledge and experience in areas of tumor biology including chromatin biology, epigenetics, and mechanism of transcriptional regulation in cancer as evidenced by publication in peer-reviewed journals.
• Strong track record in conceptualizing and advancing small molecule drug discovery programs
• Experience leading and managing laboratory-based teams with familiarity with biological assays supporting drug discovery programs
• Proficient in the use of software tools to support epigenomic data analysis including ATAC-seq, ChIP-seq, and RNA-seq.
• Experience in use of CRISPR-based techniques for gene knockout, gene editing, supporting model generation and target validations studies
• Strong communication skills--written, verbal and presentation

• Experience advancing drug discovery programs employing traditional small molecule inhibitors as well as emerging chemical proximity approaches such as protein degraders.
• Extensive experience in cancer biology including transcription factor regulation and the application of these therapeutic approaches in the clinical landscape.
• Knowledge towards integration of molecular and epigenomic (ATAC-seq, ChIP-seq) datasets, into a broader understanding of target function