Summary

At the Biologics Research Center (BRC) at BioMedical Research (BR), we are studying the Adeno-associated virus (AAV) which is a very attractive modality for gene therapy. We are now hiring an experienced Research Scientist to help further our aims in Gene therapy and treating Sickle Cell Disease.

About the Role

We are seeking a highly motivated Research Scientist with expertise in AAV gene therapies interested in joining a dynamic and experienced cell and gene therapy team at Novartis to push new frontiers in targeted vector design and gen(om)e editing. This position resides in the Cell and Gene Therapy (CGT) group within Biologic Research Center (BRC) in Basel, Switzerland. Our team drives a diverse portfolio of modalities including therapeutic proteins, multi-specific antibodies, CAR-T, RNA therapeutics, AAV and lentiviral vectors. We work collaboratively with Disease area groups to broaden the use of biologics in therapeutic applications where conventional antibodies have limitations.

• Generate novel viral constructs that address challenges in the field of gene therapy
• Applying expertise in protein engineering to improve functionality of novel AAV modalities;
• Plan and execute library screening campaigns using in vivo and in vitro selections;
• Presenting experimental design, protocols, results and interpretations in lab group and project team meetings;
• Partnering with project teams in decision making to agree on desired deliverables and timelines;
• Maintaining familiarity with current scientific literature and techniques in the field of gene therapy.

• BS or MS in virology, molecular biology, biochemistry, genetics or a related field with at least 2 years of laboratory experience (candidates with PhD will not be considered) ;

• Experience in Molecular and Cell Biology techniques.
• Experience in AAV production and characterization (e.g. AKTA purification, ddPCR, flow cytometry)

• Knowledge in library generation and in vivo / in vitro selection including NGS and data analysis is a plus;
• Curiosity, scientific agility and interest in working in matrixed and collaborative teams.
• Ability to adapt to scientific challenges and to generate innovative ideas/solutions
• Excellent communication and presentation skills in oral and written English.

• Work with the latest technologies
• Opportunity to work on the Adeno-associated virus (AAV), very attractive candidate for creating viral vectors for gene therapy
• Be part of a world class organization dedicated to providing solutions to un-met medical needs
• Join an organization that is committed to your development and advancement