Summary

Location: Basel, Switzerland

Role Purpose:
Novartis holds a rich development portfolio of small molecules ready to develop into innovative patient centric oral dosage forms. As a Formulation Project Leader working on oral dosage forms, you will lead and manage formulation and manufacturing activities linked to pharmaceutical development for small molecules (New Chemical Entities; NCE) for assigned projects. For this position, specific emphasis lies on bringing in-depth experience in applied data science, mechanistic modelling and simulation of pharmaceutical unit operations.

About the Role

Your responsibilities will include but are not limited to:

• You drive the modeling and simulation in the formulation and process development activities.
• You are accountable to develop and implement data-driven and physics-based models.
• You role-model applying data-centric ways of working by leading and implementing digital transformation initiatives in development activities.
• You role-model advanced data processing and handling.
• You support the design and development of (enabling) formulation and manufacturing process deliverables.
• You contribute to the creation and updating of formulation project plans aligned with the overall Drug Product (DP) and TRD project plans and internal guidance.
• You closely collaborate with DP sub-team members. You understand, identify and manage with them together critical aspects around DS, DP, packaging, device and analytics.
• You ensure authoring of correct, comprehensible, structured, complete and legible scientific development reports and GMP Supply documents to allow timely start of development trials, process transfers and supply activities.
• You contribute to the generation of filing dossiers, answer DP related questions in inspections and support Health Authority requests.

• Advanced degree (minimum PhD) in a relevant scientific field
• Minimum 2-4 years of successful industry experience applying data science and modeling & simulation in the development of pharmaceutical products
• Experience in implementing computational models to guide formulation and/or manufacturing processes development of drug products. For example, quantum chemistry/cheminformatics for formulation development including solubility prediction and/or energy and mass balances for manufacturing process development including granulation, blending, compression etc.
• Good knowledge of data science and data visualization
• Strong background in programming and/or machine learning
• Excellent scientific skills
• Interdisciplinary thinking and interest in collaboration with other functions
• Successfully demonstrated track record of creativity and problem solving in projects.
• Good communication, organizational, planning and negotiation skills (German language skills desired).