The Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) group is seeking a dynamic, strategic thinking and collaborative Associate Principal Scientist to contribute to our small molecule and peptide drug discovery and early clinical development efforts. This position will be based at our research labs in Boston, MA. The ideal candidate will lead drug metabolism and pharmacokinetic (DMPK) efforts as a project-team representative, regularly interacting with multi-disciplinary discovery teams and partners from other functions within our research division. Therapeutic area support with focus on our immunology and oncology portfolios, with the potential to contribute to cardiovascular/metabolic, neuroscience and infectious disease efforts as well. The successful candidate will be expected to represent PDMB on cross-functional teams through strategic design of discovery testing funnels, generation and interpretation of PK and PK/PD data sets and through effective communication at both internal meetings and external conferences.

In this exciting position, your primary roles will include:

• Project-team representative and subject matter expert on small molecule and/or peptide-based DMPK activities within the oncology and immunology therapeutic areas
• Characterization and optimization of the in vitro and in vivo ADME and pharmacokinetic properties of small molecules and peptide therapeutics
• Design, implementation and analysis of in vitro and in vivo studies to understand the impact of drug disposition on disease biology, pharmacological response (PK/PD) and safety
• Close collaboration with Discovery and Early Development project teams in Boston (MA), South San Francisco (CA) and West Point (PA) aimed at building highly efficient strategies to identify and optimize drug candidates

Education Minimum Requirement

• Ph.D (with 3+ years relevant experience), Master's (minimum of 6 years relevant experience), or Bachelor's (minimum of 12+ years relevant experience) degree in biochemistry, chemistry, pharmacology, pharmaceutical sciences, biomedical engineering or related field
• Relevant experience to include a record of increasing responsibility and independence in a similar industrial/applied academic setting

Experience and Skills (Highly preferred, must have 3/4 of listed technical skills):

• Demonstrated experience leading small molecule or peptide DMPK discovery efforts as an independent project-team representative within a highly collaborative environment
• Ability to design, optimize and interpret DMPK-related optimization strategies (discovery testing funnels) as part of a broader research operating plan
• Technical ability to analyze, interpret and provide context around data describing the ADME, pharmacokinetic and pharmacodynamic properties of small molecules or peptides, including use of software such as Phoenix WinNonlin
• Experience contributing to development and execution of translational pharmacokinetic/pharmacodynamic/efficacy relationships and other useful quantitative pharmacology applications in a discovery setting
• Strong leadership, interpersonal, communication, problem solving and collaborative qualities to deliver high quality results in a fast-paced environment

Preferred Experience and Skills

• Hands-on experience performing translational pharmacokinetic/pharmacodynamic/efficacy and physiologically-based pharmacokinetic (PBPK) software modeling (e.g., Phoenix WinNonlin, Berkeley Madonna, MATLAB).
• Ability to design and interpret novel, hypothesis-driven ADME and bioanalytical strategies (primarily LC/MS) to support the optimization of small molecule and peptide therapeutics
• Proven track record supporting immunology or oncology-based programs with experience spanning from early discovery through IND-enabling efforts
• Familiarity with structure-activity relationships aimed at improving pharmacokinetic and pharmacodynamic properties of small molecules or peptides
• Experience working within a research-driven pharmaceutical company

#EligibleforERP

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:
Regular

Relocation:
Domestic/International

VISA Sponsorship:
Yes

Travel Requirements:
10%

Flexible Work Arrangements:
Not Applicable

Shift:
Not Indicated

Valid Driving License:
No

Hazardous Material(s):
n/a

Job Posting End Date:
11/22/2024
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID:R316404