The ideal candidate will have a track record of advancing the development of biotherapeutics with mass spectrometry, as well as driving scientific excellence through external presentations and publications. Additionally, the candidate will have advanced knowledge in both analytical experimental design and biotherapeutic pipeline programs. Finally, this Associate Principal Scientist will be a partner in problem solving, building leadership, and driving collaboration both internally and externally.

Primary Responsibilities

• Perform assays including peptide mapping, intact and reduced mass, and host cell protein analysis.
• Advance mass spectrometry methodology for peptide mapping, intact mass, native mass, HDX, sequence variants, glycan analysis, quantitative analysis, and host cell protein analysis.
• Represent the mass spectrometry group in project teams.
• Author regulatory submission sections and responses, technical reports and scientific presentations.
• Explore and develop new technologies to advance the field of mass spectrometry
• Demonstrate effective multitasking, prioritization and problem-solving skills in the planning and execution of experiments.
• Mentor and share expertise across the Mass Spectrometry team.
• Champion compliance and safety as a leader both within and outside the laboratory.

Education Minimum Requirement:

• PhD in Analytical Chemistry or Chemistry plus 5+ years of relevant experience in pharmaceutical industry; or MS in Chemistry plus 8+ years or BS in Chemistry plus 12+ years of relevant industry experience

Required Experience and Skills

• A breadth and depth of analytical and biologics development understanding, including multiple modalities such as monoclonal antibodies, fusion proteins, and ADCs.
• Experience in conducting biologic mass spectrometry experiments, including sample preparation and optimization, liquid chromatography separation, mass spectrometer operation and maintenance, data interpretation, and analysis.
• Extensive knowledge of Thermo, Sciex, Agilent and Waters instruments.
• Familiarity with Genedata or other biopharma MS software.
• Excellent verbal and written communications skills, as demonstrated through high impact scientific publications and presentations.

Preferred Experience and Skills

• Expertise in multiple reaction monitoring based quantitative analysis for biologics development.
• Expertise in complex glycan analysis.
• Familiarity with R programming language for data processing, statistics and visualization.
• Advanced knowledge of electronic laboratory notebook applications and good documentation practices.

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NOTICE FOR INTERNAL APPLICANTS

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Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate's relevant skills, experience, and education.

Expected US salary range:
$135,500.00 - $213,400.00

Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. A summary of benefits is listed here.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:
Regular

Relocation:

VISA Sponsorship:

Travel Requirements:

Flexible Work Arrangements:
Not Applicable

Shift:

Valid Driving License:

Hazardous Material(s):

Job Posting End Date:
10/15/2024
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Job Posting End Date:10/15/2024

A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID:R314228