Johnson & Johnson is recruiting for a Senior Scientist, Biochemistry to join our team in Spring House, PA.
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/.
For more than 130 years, diversity, equity & inclusion (DEI) has been a part of our cultural fabric at Johnson & Johnson and woven into how we do business every day. Rooted in Our Credo, the values of DEI fuel our pursuit to create a healthier, more equitable world. Our diverse workforce and culture of belonging accelerate innovation to solve the world's most pressing healthcare challenges.
Want more jobs like this?
Get jobs in Spring House, PA delivered to your inbox every week.
We know that the success of our business - and our ability to deliver meaningful solutions - depends on how well we understand and meet the diverse needs of the communities we serve. Which is why we foster a culture of inclusion and belonging where all perspectives, abilities and experiences are valued and our people can reach their potential.
At Johnson & Johnson, we all belong.
The Lead Discovery & Mechanistic Pharmacology team is a critical part of the Therapeutics Discovery (TD) organization in Johnson & Johnson Innovative Medicine and is committed to the delivery of high-quality chemical leads needed for the generation of small molecule clinical compounds in all five J&JIM Therapeutic Area (TA) discovery teams. This mission requires deep cross-disciplinary scientific expertise including chemistry, cellular and molecular pharmacology, enzymology, and screening technologies, coupled with an ability to work collaboratively with internal and external partners.
Building on a strong legacy of success, we are currently seeking an outstanding individual to join our team as a Senior Scientist in the Enzymology group. This position will report to a senior member of the Lead Discovery & Mechanistic Pharmacology (LD&MP) Enzymology team
Key Responsibilities:
- This position is 85% lab-based with a requirement for on-site work.
- Provide enzymology & protein biochemistry subject matter expertise to internal program teams and external collaborations.
- Characterize complex target proteins and enzymes, their substrates, and reaction mechanisms to support hit identification and validation, and influence drug discovery program teams.
- Independently design, develop, and implement novel biochemical assays to drive small molecule lead identification through candidate declaration.
- Coordinate development, execution, and triage of high-throughput screening campaigns and represent the biochemistry functional group in drug discovery matrix teams.
- Conduct mechanistic studies on small molecule enzyme modulators, including mode of inhibition, time-dependence, and mutual exclusivity analysis.
- Differentiate biochemical and cellular mechanisms of action of hit molecules to guide SAR and structural approaches to lead optimization.
Qualifications
Education:
- Minimum of a MS degree with 9 years or Ph.D. degree with 0-3 years of experience in Enzymology, Biochemistry, Biophysics, and/or Pharmacology.
Experience and Skills:
Required:
- Subject area mastery in key areas including biochemical assay development, enzyme characterization, mechanism-of-inhibition studies, time-dependence, steady-state kinetics, and protein biochemistry is required.
- Strong capabilities to collaborate with scientists in various scientific fields and effectively present key data and findings to program teams is required.
- Ability to work highly independently and take on individual responsibility for driving key program deliverables.
- Exceptional written and oral communication skills is required.
Preferred:
- Strong record of publications is highly preferred.
- Basic familiarity with biophysical techniques and their applications (SPR, MST, ThermoFluor) is preferred.
- Experience/Knowledge in Oncology, Immunology, Cardiovascular & Metabolic Diseases, or Neuroscience areas is preferred.
- Familiarity with large dataset analytics tools (GeneData Screener, Spotfire, etc.) is preferred.
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.