Johnson & Johnson is currently seeking a Senior Associate Scientist, Neuropharmacology in the Lead Evaluation and Cellular Pharmacology team located in San Diego, CA.
Lead Evaluation and Cellular Pharmacology (LECP) plays an important role in the Therapeutics Discovery organization, where scientific expertise in screening, pharmacology, and chemistry is harnessed to develop groundbreaking new medicines in the areas of Neuroscience, Immunology, and Oncology.
We are seeking a highly motivated Senior Associate Scientist with extensive experience in receptor pharmacology to join the LECP team in La Jolla. In this position, the Scientist will spend the bulk of their time in the lab, setting up and running assays, in addition to analyzing and reporting data. Qualified candidates should be motivated to generate and share results, enjoy working closely with other colleagues across functional teams, and comfortable balancing their efforts between multiple research programs. In addition to scientific rigor, the job duties of the Scientist will depend upon a comprehensive understanding of high-throughput screening and assay development. It is crucial that they display enthusiasm to develop proficiency in any tasks where their prior experience is limited.
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Key Responsibilities:
- Use automated electrophysiology, FLIPR, and other technical platforms to run weekly membrane receptor assays in support of medicinal chemistry efforts
- Participate in the development, optimization, and troubleshooting of new assays
- Conduct medium to high-throughput screening for neurological disease targets
- Analyze experimental data rapidly, while ensuring the quality and consistency of reported datasets
- Derive key findings from the interpretation of assay results, and communicate those to the larger project team at meetings
- Prepare graphical illustrations of results in a form accessible to biology and chemistry partners
Qualifications
Education:
- BS or MS in Neuroscience, Pharmacology, or a related biology field
Experience and Skills:
Required:
- Minimum of 8 years laboratory experience in an industry setting
- Proficiency performing and analyzing manual and/or automated patch-clamp electrophysiology experiments
- Strong understanding of ion channel gating processes and membrane receptor pharmacology
- Familiarity with mammalian cell culture; ability to maintain multiple cell lines
- Proven analytical and problem-solving skills
- Excellent writing skills, including a track record of first author peer-reviewed publication in respected journals
- Strong oral communication skills and willingness to regularly present results to multidisciplinary project teams
- Flexibility to shift focus between multiple projects on a daily/weekly basis
Preferred:
- Practical knowledge of high-throughput cell-based assays is highly desirable, especially involving membrane receptor signaling (i.e. FLIPR)
- Familiarity with the principles of small molecule library screening and early-stage drug development
- Proficiency with standard scientific software used for data analysis and record-keeping (e.g. GraphPad Prism, Genedata Screener, Signals Notebook)
The anticipated base pay range for this position in the U.S. is $$88,000 - $141,450.
The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation's performance over a calendar/ performance year. Bonuses are awarded at the Company's discretion on an individual basis.
Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. Employees may be eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)). This position is eligible to participate in the Company's long-term incentive program. Employees are eligible for the following time off benefits:
- Vacation - up to 120 hours per calendar year
- Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington - up to 56 hours per calendar year
- Holiday pay, including Floating Holidays - up to 13 days per calendar year
- Work, Personal and Family Time - up to 40 hours per calendar year
For additional general information on Company benefits, please go to: https://www.careers.jnj.com/employee-benefits
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com