Johnson & Johnson is currently seeking a Principal Scientist (In Vivo) Oncology located in Spring House, PA. A preidentified candidate has been identified, however, all applicants will be considered. At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/.
For more than 130 years, diversity, equity & inclusion (DEI) has been a part of our cultural fabric at Johnson & Johnson and woven into how we do business every day. Rooted in Our Credo, the values of DEI fuel our pursuit to create a healthier, more equitable world. Our diverse workforce and culture of belonging accelerate innovation to solve the world's most pressing healthcare challenges. We know that the success of our business - and our ability to deliver meaningful solutions - depends on how well we understand and meet the diverse needs of the communities we serve. Which is why we foster a culture of inclusion and belonging where all perspectives, abilities and experiences are valued and our people can reach their potential. At Johnson & Johnson, we all belong.
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The Principal Scientist will join the Oncology in vivo group efforts in the characterization and development of small molecules, biologics, and cell therapies including those that function as immune modulators for the treatment of cancer. Leads project team in the design and execution of Pharmacology research programs to meet project objectives, including complex controlled experiments to understand the effects of drug candidates and compound activity in tissues, cells, and sub-cellular preparations derived from animals and/or humans and/or technology platform development. Acts as a developing subject matter expert and individual contributor who significantly advances research to support discovery and development objectives; may be trained to become a cross-department project team leader. Leads implementation of pharmacology models (multiple programs and/or platforms) and process flow for compound screening and profiling. Interprets complex datasets and effectively communicates impact to stakeholders through formal and informal disclosures. Specifically, the candidate will establish and perform in vivo model development, target inhibition, efficacy, mechanism of action, and pharmacokinetic/pharmacodynamics (PK/PD) biomarker studies, and will evaluate the influence of dose, schedule and therapeutic combinations in various cancer models.
Recognizes and documents intellectual property and enters, reviews, and audits all project information to ensure that it is recorded and retained according to established procedures. Uses developments in emerging fields to generate new research ideas and initiatives based on long-term needs, typically collaborating externally (e.g., academics, biotech, CROs, external experts). Ensures compliance with company standard operation procedures and other regulatory guidelines. Contributes to overall strategic project planning and may be responsible for presenting integrated research strategies in order to make recommendations and influence senior leaders for project decisions. Builds internal and external reputation and network through publications and presentations. Coaches and trains junior colleagues in techniques, processes and responsibilities. Integrates Johnson & Johnson's Credo and Leadership Imperatives into team goals and decision-making.
Additional Responsibilities:
- Works under minimal supervision and leads in vivo portions of a program, project, and/or process and provides training and guidance to technical staff.
- Provides scientific/technology subject matter expertise to establish operational plans and implement products, processes, and standards that have some impact on business results.
- Establish and perform in vivo model development, including the improvement, adaptation, or change to existing research methods, or adaptation from scientific literature.
- May contribute to ex vivo analysis of tumor or immune cells by flow cytometry, IHC, ELISA, RT-PCR, or Luminex®.
- May perform bioluminescent imaging studies using molecular reporters or disseminated/ metastatic disease models.
- Manage multiple in vivo projects simultaneously, including coordination with project leaders and other functions.
- May supervise/manage non-Ph.D. scientists.
- Manage external research studies.
- Analyze data using appropriate statistical methods and present data in a professional format suitable for external publication.
- Applies in-depth knowledge and experience to address complex problems that require an understanding of one or multiple related disciplines.
- Act as an expert resource on project teams and demonstrate clear and professional verbal and written communication.
- Some weekend, evening, and holiday dosing / animal monitoring required.
Qualifications
- Bachelor's degree (BS/ BA) in the life sciences (molecular/ cellular biology, biochemistry, pharmacology, tumor immunology) with at least 10 years of relevant pharmaceutical or biotech industry/ lab/ academic experience OR a Master's degree (MS) with at least 6 years of relevant experience, or PhD with 4 years of relevant post-graduate experience.
- Ability for cell culture of cancer or immune cells is preferred.
- Experience with oncology-relevant rodent models - xenografts and syngeneic models are required; primary grafts, orthotopic models, humanized models, or genetically engineered tumor models is required.
- Experience with small molecules and/ or biologics is required.
- Experience with immune-modulatory agents, vaccines or cell therapies such as CAR-Ts is desirable.
- Strong skills in tumor implantation techniques and dosing, proper handling of therapeutics, tumor measurement, health monitoring, and data collection and analysis are required.
- Experience with bioluminescent imaging, flow cytometry, IHC, ELISA, RT-PCR, Westerns, or Luminex® is desirable.
- Strong organizational skills including the ability to manage several projects simultaneously; detail oriented with excellent record keeping skills are required.
- Excellent interpersonal skills with the ability to interact effectively with people, internally and externally, is required.
- Excellent data management and record-keeping skills are required.
- Ability to effectively present scientific data and concepts to colleagues and teams is critical, and experience presenting at external meetings is also required.
- Proven track record of adherence to animal welfare and compliance regulations is critical.
- Experience in writing technical drafts for patent filings, IND (US-FDA) or CTA (EMA) filings are desirable.
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com.