Are you seeking an exciting opportunity in drug discovery research? Join our team of motivated and collaborative scientists at CSL Global Research, located in the vibrant research hub of Zurich BIO-TECHNOPARK® Schlieren. As a Senior Scientist: Rare Renal Diseases / Complex Cellular Models, you will conduct research to deepen our understanding of disease mechanisms. You'll develop cutting-edge human cellular models to validate therapeutic targets and drive projects with the aim of expanding our portfolio of renal disease assets from early discovery through clinical stages. You will be directly reporting to the Head of Cellular Pharmacology & Imaging Zurich.

We offer a flexible working model that balances on-site and home office arrangements, while highly encouraging on-site presence to foster collaboration, innovation, and ensure smooth lab operations. We welcome applications from candidates passionate about innovation, teamwork, and improving the lives of patients with rare renal diseases.

• Working together with and providing expertise to research project teams in order to achieve specified research project objectives within defined time parameters.
  
• Conception of new research projects to contribute to the CSL drug discovery portfolio in the area of rare renal diseases like polycystic kidney disease.
  
• Providing scientific guidance to lab technicians and scientists developing in vitro cellular models, including hands-on lab work in establishing novel and complex methods and technologies.
  
• Planning, executing, and analyzing in vitro preclinical pharmacology experiments at the highest levels of scientific integrity.
  
• Managing external collaborations with CROs and academic collaborators to deliver data at the highest levels of scientific integrity.
  
• Providing preclinical research expert input to late-stage development and marketed drugs.
  
• Supporting business development activities by providing preclinical research expertise in the process of due-diligence of in-licensing opportunities.
  
• Continuous adequate further training.
  
• Compliance with technical, organizational and staff safety measures.
  

• PhD and/or MD degree in life sciences.
  
• At least 2 years of postdoctoral research experience in industrial or academic setting with a focus in renal or cardiovascular disease areas.
  
• A proven scientific impact on innovation through a solid publication track record.
  
• Deep knowledge of kidney physiology and pathophysiology of kidney polycystic disease.
  
• Strong hands-on experience in developing and executing complex cellular renal disease models, hands-on experience with human iPSC-derived models is a plus.
  
• Strong hands-on experience in a wide range of biochemical, imaging and genome editing methods and technologies to unravel complex molecular signaling pathways.
  
• Experience in designing and interpreting in vivo pharmacology experiments.
  
• Knowledge and routine application of relevant statistical methods for data analysis.
  
• Confident use of collaboration and scientific IT software.
  
• Highly effective verbal and written communication skills in English language.
  
• Ability to effectively interact with people in a dynamic matrix environment, both internally and externally.
  
• Strong commitment to quality, accuracy, and technical details.
  
• Excellent organizational and time management skills and independence in execution of tasks.
  
• Innovative, entrepreneurial attitude with a solution-oriented and pro-active work style.