Job Description

About This Role

Drug Metabolism and Pharmacokinetics (DMPK) group in Biogen is seeking an enthusiastic Senior Associate Scientist for the identification of drug metabolites and some metabolizing enzymes, to support the discovery and development of innovative therapies for people living with neurological and rare diseases. The position is located at Cambridge, MA. It has great opportunities for growing and executing the skills and expertise in biotransformation, as well as for interactions with medicinal chemists and scientists in other functions.

What You’ll Do

• Identification and structural elucidation of drug metabolites in vitro (e.g., liver microsomes and hepatocytes, etc.) and in vivo (e.g. plasma and urine, etc.) using liquid chromatography - high resolution mass spectrometry (LC-MS; to be more specific, LC-HRMS).
• In vitro incubations to generate drug metabolite samples and to investigate the biotransformation mechanisms.
• Occasional purification of in vitro or in vivo drug metabolite sample for NMR structural identification.
• Conduct a limited number of radiolabeled metabolite profiling and identification studies, e.g., of 14C or 3H labeled candidate drugs in vivo and in vitro.
• Draft/write study reports on metabolite identification and biotransformation.
• Perform some in vitro metabolic reaction phenotyping to identify drug metabolizing enzymes.

Who You Are

A junior or entry level scientist who enjoys problem/puzzle-solving and likes operating analytical instruments would be better suited for this job.

Qualifications

• Bachelor’s or master’s degree in chemistry, analytical chemistry, medicinal chemistry, or a related discipline, with 2-4 years’ experience for Bachelor or 0-2 years’ experience for Master.
• Hands-on experience in liquid chromatograph and/or mass spectrometry
• Strong essential understanding of organic chemistry and general chemistry
• Capable of handling in vitro and in vivo biological samples
• Good communication skills

Preferred Qualifications

• Hands-on experience in high resolution mass spectrometry.
• Knowledge in drug metabolism and metabolizing enzymes.

Additional Information

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.